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Human & Experimental Toxicology
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Effect of meso-2,3-dimercaptosuccinic acid on urinary lead excretion in exposed men

O Torres-Alanís

Centro Antivenenos, Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Apartado Postal 146, Col. del Valle, Monterrey, Nuevo León, México; otorres{at}ccr.dsi.uanl.mx

L Garza-Ocañas

A Piñeyro-López

Centro Antivenenos, Departamento de Farmacología y Toxicología, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México

The efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) was evaluated in workers occupationally exposed to lead (Pb; blood level >50 mg //dL). Ten men were given 600 mg of DMSA per orem daily, for five days. Pb concentrations of whole blood and urine were determined throughout therapy. Hematology analyses, blood chemistry, and urinalysis were obtained at the start of the study, at the end of the DMSA treatment, and at 72 hours after the administration of the final dose. DMSA therapy had no influence on hepatic, hematologic, or renal functions and was effective in decreasing the concentration of blood Pb in all the subjects without adverse drug reactions.

Key Words: DMSA • lead • occupational exposure

Human & Experimental Toxicology, Vol. 21, No. 11, 573-577 (2002)
DOI: 10.1191/0960327102ht280oa
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