This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Tsatsakis, A M Articles by Tzanakakis, G N Search for Related Content PubMed PubMed Citation Articles by Tsatsakis, A M Articles by Tzanakakis, G N Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB ATROPINE FENTHION Medline Plus Health Information Poisoning Social Bookmarking                         What's this?

Severe fenthion intoxications due to ingestion and inhalation with survival outcome

Laboratory of Toxicology, Medical School, University of Crete, Voutes, Heraklion 71409, Crete, Greece; PO Box 1393; aris{at}med.uoc.gr

G K Bertsias

Laboratory of Toxicology, Medical School, University of Crete, Voutes, Heraklion 71409, Crete, Greece

V Liakou

Laboratory of Toxicology, Medical School, University of Crete, Voutes, Heraklion 71409, Crete, Greece

I N Mammas

I Stiakakis

Laboratory of Toxicology, Medical School, University of Crete, Voutes, Heraklion 71409, Crete, Greece

G N Tzanakakis

Department of Histology, Medical School, University of Crete, Voutes, Heraklion 71409, Crete, Greece

Two cases of severe fenthion intoxication are presented. The first is a case of a psychiatric patient who attempted suicide with ingestion of the compound, and the second case was of a child exposed to the chemical agent by air spraying. Both patients were treated in the intensive care unit with atropine and pralidoxime and finally survived. Fenthion blood levels on admission were 2.7 and 0.95 µg/mL, respectively. Different concentrations of pralidoxime were added to the first patient's poisoned serum in order to assess in vitro the effect of pralidoxime on cholinesterase reactivation. The clinical and toxicological data of the poisonings are discussed, as well as the potential therapeutic use of pralidoxime in organophosphate intoxication.

Key Words: fenthion • ingestion • inhalation • mass spectrometry • poisoning • pralidoxime

Human & Experimental Toxicology, Vol. 21, No. 1, 49-54 (2002)
DOI: 10.1191/0960327102ht232cr


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?