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Effects of prenatal exposure to combination of acetaminophen, isopropylantipyrine and caffeine on intrauterine development in rats

Experimental Teratology Unit, Human Anatomy Department, Medical University of Lublin, 1 Spokojna Str., Lublin PL-20-074, Poland; fb3{at}wp.pl

The common effects of acetaminophen (paracetamol), isopropylantipyrine (propyphenazone) and caffeine on fetal development were examined in rats. The mixture was given in Tween 80 solution once daily, in a constant proportion of 5:3:1, during days 8–14 of gestation in three different doses. Dose S₁–3.5 mg/kg acetaminophen, 2.14 mg/kg isopropylantipyrine, 0.7 mg/kg caffeine. Dose S₂ was 10 times higher, and S₃ 100 times higher than dose S₁. On day 21 of gestation, the dams were sacrificed and the fetuses were removed. The corpora lutea, resorptions, live and dead fetuses were counted. The pre-and postimplantation mortality were calculated. The weight of fetuses and placentas, and the length of fetuses and their tails were measured. Two-thirds of each litter was processed for Alizarin Red S staining. The remaining third was fixed in Bouin's solution for subsequent visceral examination by using modified Wilson's technique. A significant decrease in body weight in S₁ group, and fetal length and placental weight in group S₃ were recorded. A significant increase in tail length in group S₂ was observed. The number ofcorpora lutea, fetuses, resorptions, preimplantation and postimplantation mortality did not exhibit any significant difference. Nonsignificant incidence of fetal anomalies was found.

Key Words: acetaminophen • caffeine • isopropylantipyrine • OTC • paracetamol • pregnancy • prenatal toxicity • propyphenazone • rat

Human & Experimental Toxicology, Vol. 21, No. 1, 25-31 (2002)
DOI: 10.1191/0960327102ht224oa


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