This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Ohtake, T Articles by Hishida, A Search for Related Content PubMed PubMed Citation Articles by Ohtake, T Articles by Hishida, A Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB GLUTAMIC ACID HYDROCHLORIDE Social Bookmarking                         What's this?

Decreased plasma and cerebrospinal fluid glutamine concentrations in a patient with bialaphos poisoning

Department of Medicine, Fujinomiya City General Hospital, 3-1, Nishiki-cho Fujinomiya 418-0076, Japan

H Yasuda

First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

H Takahashi

Department of Neurosurgery, Fujinomiya City General Hospital, Fujinomiya, Japan

T Goto

First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

K Suzuki

Second Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

K Yonemura

Hemodialysis Unit, Hamamatsu University School of Medicine, Hamamatsu, Japan

A Hishida

First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

A 47-year-old Japanese woman undergoing maintenance hemodialysis (HD) was admitted to our hospital because of poisoning with the herbicide bialaphos. Respiratory arrest and loss of consciousness ensued rapidly, accompanied by convulsions and nystagmus. Treatment with HD and direct hemoperfusion, followed by HD alone, effectively removed bialaphos and its chief toxic metabolite (L-AMPB) from the circulation (bialaphos decreased from 0.33 to <0.05 g/ml andL-AMPBfrom14to0.86 g/ml). The glutamate concentration improved gradually after the removal of bialaphos and L-AMPB from plasma (plasma glutamate concentration: 250.4 nmol/l on day 5 to 120.6 nmol/l on day 26). Decreased glutamine concentration in cerebrospinal fluidwasdemonstratedforthefirsttimeaswellasinplasma, indicating glutaminesynthetase inhibition notonlyinplants but also in humans by bialaphos poisoning.

Key Words: bialaphos poisoning • direct hemoperfusion • glutamate • glutamine • hemodialysis • herbicide

Human & Experimental Toxicology, Vol. 20, No. 8, 429-434 (2001)
DOI: 10.1191/096032701682692973


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?