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Human & Experimental Toxicology
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Reproductive toxicity of DDT in adult male rats

K Ben Rhouma

O Tébourbi

R Krichah

M Sakly

Laboratoire de Physiologie Animale, Faculté des Sciences de Bizerte, Jarzouna 7021, Tunisia

The reproductive toxicity of DDT was investigated in adult male rats exposed to 50 and 100 mg/kg body weight (b.wt) day 1 for 10 successive days. Compared with control animals, administration of DDT led to a dose-dependent reduction of testicular weight and the number as well as the percentage of motile spermatozoa in the epididymis. Testicular histological observationsrevealed alsoamarkedloss of gametes in the lumen of seminiferous tubules. In DDT treated rats, the seminal vesicles weights dropped significantly, resulting from a decrease of testosterone production by testes, whereas serum LH and FSH increased after pesticide exposure. This increase of gonadotrophin levels may be related to an impairment of the negative feedback exerted by the steroid on the hypothalamic–pituitary axis. It is concluded that DDT induced adverse effects on male rat fertility by acting directly on the testes and altering the neuroendocrinefunction.

Key Words: DDT • rat • fertility • testes • gonadotrophins

Human & Experimental Toxicology, Vol. 20, No. 8, 393-397 (2001)
DOI: 10.1191/096032701682692946
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