This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Balkan, J Articles by Uysal, M Search for Related Content PubMed PubMed Citation Articles by Balkan, J Articles by Uysal, M Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Cirrhosis Hazardous Substances DB MALONALDEHYDE THIOACETAMIDE Social Bookmarking                         What's this?

Taurine has a protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress

S Dogru-Abbasolul

ö Kanbaglil

Department of Biochemistry, Istanbul Medical Faculty, University of Istanbul, (papa, 34390, Istanbul, Turkey

U Çevikbas

Department of Pathology, Istanbul Medical Faculty, University of Istanbul, 1tapa, 34390, Istanbul, Turkey

G Aykaç-Toker

M Uysal

Department of Biochemistry, Istanbul Medical Faculty, University of Istanbul, (papa, 34390, Istanbul, Turkey

Thioacetamide (TAA) administration (0.3 g/l of tap water for a period of 3 months) to rats resulted in hepatic cirrhosis as assessed by biochemical and histopathological findings. This treatment caused an increase in the levels of malondialdehyde (MDA) and diene conjugates (DCs) and a decrease in the levels of glutathione (GSH), vitamin E, vitamin C and the activities of glutathione peroxidase (GSH-Px) in the liver of rats. Superoxide dismutase (SOD) activities were unchanged. Taurine (2% w/w, added to the chow diet) was administered together with TAA (0.3 g/l of drinking water) for 3 months. Taurine was found to decrease TAA-induced hepatic lipid peroxidation and to increase TAA-depleted vitamin E levels and GSH-Px activities. Histopathological findings also suggested that taurine has an inhibitive effect on TAA-induced hepatic cirrhosis. These results indicate that taurine treatment has a protective effect against TAAinduced liver cirrhosis by decreasing oxidative stress.

Key Words: taurine • thioacetamide • liver cirrhosis • lipid peroxidation • antioxidants • rats

Human & Experimental Toxicology, Vol. 20, No. 5, 251-254 (2001)
DOI: 10.1191/096032701678227758


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S J. Flora, M. Pande, S. Bhadauria, and G M Kannan Combined administration of taurine and meso 2,3-dimercaptosuccinic acid in the treatment of chronic lead intoxication in rats Human and Experimental Toxicology, April 1, 2004; 23(4): 157 - 166. [Abstract] [PDF]

				S DogIru-AbbasogIlu, J Balkan, O KanbagIlo, U Cevikbas, G Aykac-Toker, and M Uysal Aminoguanidine, an inducible nitric oxide synthase inhibitor, plus N-acetylcysteine treatment reduce the lipopolysaccharideaugmented hepatotoxicity in rats with cirrhosis Human and Experimental Toxicology, July 1, 2002; 21(7): 359 - 364. [Abstract] [PDF]