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Reduction of uranium transfer by local chelation in simulated wounds in rats

Institut de Protection et de Sûtreé Nucleaire, Département de Protection de la sant6 de l'Homme et de Dosimétrie, Service de Dosimetrie, BP no. 6, F 92265 Fontenay aux Roses cedex, France; IPSN/SDOS/LEAR CEN VALRHO, BP 38, 26701 Pierrelatte cedex, France

V Chazell

F Paquet

Institut de Protection et de Sutret6 Nucleaire, Departement de Protection de la sant6 de l'Homme et de Dosimetrie, Service de Dosimetrie, BP no. 6, F 92265 Fontenay aux Roses cedex, France

T Bailly

R Burgada

Universite Pierre et Marie Curie, 4 place Jussieu, 75230 Paris cedex 5, France

M H Henge-Napolil

Institut de Protection et de Sutret6 Nucleaire, Departement de Protection de la sant6 de l'Homme et de Dosimetrie, Service de Dosimetrie, BP no. 6, F 92265 Fontenay aux Roses cedex, France

The aim of the paper is to develop a new approach to treat uranium-contaminated wounds. The efficacy of a local uranium chelator, carballylic amido bis phosphonic acid (CAPBP) was assessed using two different uranium compounds. Rats were contaminated by intramuscular injections of uranyl nitrate or an industrial U0₄ compound to simulate wound contamination. CAPBP was injected intramuscularly (im) or intraperitoneally (ip) at a dosage of 30,umol kg-. In one experiment, the local administration of CAPBP was combined with a systemic administration of ethane-1-hydroxy-1,1-biphosphonate (EHBP). The local CAPBP treatment resulted in increased retention of uranium at the wound site: about 30% for uranyl nitrate or U0₄ after the first day and about 15% of U0₄ after the third day. Consequently, it reduced uranium translocation into the blood and deposition in the kidneys and bone. The combined treatment reduced the uranium deposits in the kidneys, bone and carcass to about one-half of those observed in controls 3 days after U0₄ contamination. The local CAPBP treatment increased the interval of time between contamination and uranium deposit in the target organs. Thus, it can increase the efficacy of nonspecific local treatments or specific systemic treatments. It could be given rapidly through spray or gel after an accident.

Key Words: uranium • wound • rat • treatment

Human & Experimental Toxicology, Vol. 20, No. 5, 237-241 (2001)
DOI: 10.1191/096032701678227721


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