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Human & Experimental Toxicology
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Diepoxybutane and mitomycin C toxicity is associated with the induction of oxidative DNA damage in sea urchin embryos

G Pagano

G. Pascale Foundation, Italian National Cancer Institute, via M. Semmola, I-80131 Naples, Italy

P Degan

National Cancer Research Institute, IST, L. R. Benzi, 10, I-16132 Genoa, Italy

A De Biase

M Iaccarino

G. Pascale Foundation, Italian National Cancer Institute, via M. Semmola, I-80131 Naples, Italy

M Warnau

International Atomic Energy Agency, Quai Antoine Premier, BP 800, MC-98012, Monaco

Diepoxybutane (DEB)-and mitomycin C (MMC)-associated toxicity was investigated in embryos from the sea urchin (SU) species Sphaerechinus granularis. DEB-and MMC-induced toxicity resulted in S. granularis embryos and larvae at concentrations ranging 10 5 to 10 4 M DEB, and 3 10 3International Atomic Energy Agency, Quai 6 to 3 10 5 M MMC, in terms of larval malformations, developmental arrest and mortality. The formation of DNA oxidative damage, 8-hydroxy-20-deoxyguanosine (8-OHdG) was measured in DEB-and in MMC-exposed embryos (at gastrula stage). A dose-dependent increase in 8-OHdG levels was observed that was significantly correlated with DEB-and MMC-induced developmental defects. The results lend further support to the body of evidence associating both DEB and MMC toxicity with oxidative stress, including DNA oxidative damage. Human & Experimental Toxicology (2001) 20, 651–655.

Key Words: diepoxybutane • mitomycinC • DNAoxidativedamage • 8-hydroxy-20-deoxyguanosine • seaurchins • developmentaldefects • Fanconi’ • sanaemia

Human & Experimental Toxicology, Vol. 20, No. 12, 651-655 (2001)
DOI: 10.1191/096032701718890577
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