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Nephrotoxicity of Phenazopyridine

Departments of Medicine, Clinical Pharmacology and Morbid Anatomy, University College London School of Medicine, London WC1E 6JJ

S.L. Cohen

Departments of Medicine, Clinical Pharmacology and Morbid Anatomy, University College London School of Medicine, London WC1E 6JJ

M.R. Smith

Departments of Medicine, Clinical Pharmacology and Morbid Anatomy, University College London School of Medicine, London WC1E 6JJ

C. Fisher

Departments of Medicine, Clinical Pharmacology and Morbid Anatomy, University College London School of Medicine, London WC1E 6JJ

1 A young man developed reversible acute renal failure after a large overdose of phenazopyridine.

2 The renal failure was treated by peritoneal dialysis.

3 Analysis of blood and urine samples failed to demonstrate the parent drug but a metabolite with similar ultraviolet absorption was detected.

4 No parent drug or metabolites were detected in the peritoneal dialysate.

Human & Experimental Toxicology, Vol. 2, No. 3, 539-543 (1983)
DOI: 10.1177/096032718300200311


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