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Acute Dapsone Poisoning: Clinical Features and Pharmacokinetic Studies

Wolfson Unit of Clinical Pharmacology, The University

D.B. Henderson

Wolfson Unit of Clinical Pharmacology, The University

B. Charlton

Wolfson Unit of Clinical Pharmacology, The University

R.T. Peaston

Department of Clinical Biochemistry, Freeman Hospital, Newcastle upon Tyne

M.D. Rawlins

Wolfson Unit of Clinical Pharmacology, The University

1 A case of acute dapsone poisoning in a 57 year old man is reported. Peak plasma dapsone concentrations of 18.8 mg/l were observed 20 hours after ingestion, and methaemoglobin concentrations fell in parallel with dapsone.

2 Plasma dapsone concentrations declined mono-exponentially with time, and the half-life (29.7 hours) was similar to that described in subjects receiving conventional doses. Moreover, the ratio of monoacetyl-dapsone (MADDS) to dapsone remained constant as plasma concentrations fell. These observations suggest that N-acetylation of dapsone was not saturated even at the toxic concentrations observed.

Human & Experimental Toxicology, Vol. 2, No. 3, 507-510 (1983)
DOI: 10.1177/096032718300200306


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