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The Mechanism of Paracetamol-induced Hepatotoxicity: Implications for Therapy

Department of Clinical Pharmacology, Royal Postgraduate Medical School, Ducane Road, London W12 OHS

I.A. Blair

Department of Clinical Pharmacology, Royal Postgraduate Medical School, Ducane Road, London W12 OHS

1 The reactive metabolite responsible for paracetamol-induced hepatotoxicity, postulated to be N -acetyl-p-benzoquinoneimine reacts with N-acetyl cysteine.

2 An adduct is formed by an S_N2 mechanism and paracetamol is produced by a redox reaction.

3 The adduct produced is capable of further oxidation by N-acetyl-p-benzoquinoneimine.

4 Methionine does not react with the reactive metabolite to any great extent.

Human & Experimental Toxicology, Vol. 2, No. 2, 399-405 (1983)
DOI: 10.1177/096032718300200238


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