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Recent Advance in the Therapy of Metal Poisonings with Chelating Agents

Institute of Occupational Health, P.O. Box 8149 Dep., OSLO 1, Norway

A survey is given of the use of chelating agents in the treatment of metal poisonings.

1 The complexing agents in established clinical use are the polyaminopolycarboxylic acid EDTA (ethylenediamine tetraacetate) and the thiols BAL (2, 3-dimercaptopropanol) and D-penicillamine. Desferrioxamine is useful in the treatment of iron overloading.

2 The theoretical foundation of the metal-ligand interaction and some general principles of value in the search for new metal antidotes are outlined.

3 Recent research has shown that 2, 3-dimercaptosuccinic acid (DMS) and 2, 3-dimercaptopropane-1-sulphonate (DMPS) are effective in mercury and arsenic poisonings.

4 DMS and DMPS are of significantly lower toxicity than BAL, and they can be administered orally or intravenously.

5 A particularly low toxicity of DMS is reported from clinical and experimental studies, and this agent may be useful against several metal poisonings including mercury, lead and gold.

Human & Experimental Toxicology, Vol. 2, No. 2, 257-272 (1983)
DOI: 10.1177/096032718300200214


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