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Naloxone and Alcohol Intoxication in the Dog

Emergency Department, Erasme Hospital, Université Libre de Bruxelles

Jeanine Fontaine

Institute of Pharmacology, Université Libre de Bruxelles, Belgium

Robert Askenasi

Emergency Department, Erasme Hospital, Université Libre de Bruxelles

1 The effects of naloxone upon ethanol-induced coma have been investigated in dogs. In a double blind study, 15 mongrel dogs received ethanol i.v. (4 g/kg) followed by a single dose of naloxone (12 ?g/kg).

2 Naloxone failed to affect either the duration of respiratory arrest or the time to recovery of motor coordination. In similar animals treated with the narcotic analgesic, fentanyl, naloxone induced a dramatic and complete reversal of the narcotic effects within 30 seconds.

3 It is concluded that, if naloxone has any effect in alcoholic coma, it is not comparable with its dramatic action in narcotic coma.

Human & Experimental Toxicology, Vol. 2, No. 2, 221-225 (1983)
DOI: 10.1177/096032718300200208


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