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In Vitro and In Vivo Evaluation of Two Preparations of Activated Charcoal as Adsorbents of Aspirin

Poisons Unit, Guy's Hospital, London

S. Chand

Poisons Unit, Guy's Hospital, London

R.A. Braithwaite

Poisons Unit, Guy's Hospital, London

P. Crome

Poisons Unit, Guy's Hospital, London

1 The adsorptive capacities of two preparations of activated charcoal have been studied both in vitro and in vivo using aspirin as a test compound.

2 The in vitro adsorptive capacities of the charcoal preparations were 477 mg of acetylsalicylic acid/g effervescent charcoal ('Medicoal'); 359 mg/g untreated standard charcoal ('Norit-A') and 482 mg/g reheated charcoal ('Norit A').

3 In vivo both charcoal preparations significantly reduced peak salicylate concentrations and salicylate availability, to a similar extent (analysis of variance P < 0.001).

4 Both charcoal preparations have similar capacities for adsorbing aspirin both in vitro and in vivo.

Human & Experimental Toxicology, Vol. 2, No. 2, 211-216 (1983)
DOI: 10.1177/096032718300200206


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