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Activated Charcoal in Tricyclic Antidepressant Poisoning: Pilot Controlled Clinical Trial

R. Adams

Accident Departments of Guy's, Norfolk and Norwich, Guy's Hospital, London SE1 9RT

C. Ali

V. Dallos

Whipps Cross Hospitals and Poisons Unit, Guy's Hospital, London SE 1 9RT

S. Dawling

1 A randomised clinical trial was carried out to assess the effects of activated charcoal in the management of suspected tricyclic antidepressant poisoning.

2 Forty-eight patients entered the study, twenty receiving supportive care plus activated charcoal (10 g) and twenty-eight supportive care alone.

3 Drug screening showed that only seventeen patients had taken tricyclic antidepressants alone.

4 Activated charcoal had no effect on either the rate of lightening of coma or the fall in plasma antidepressant concentrations in the 'pure' tricyclic antidepressant poisoning group.

5 No serious side-effects of activated charcoal were reported.

Human & Experimental Toxicology, Vol. 2, No. 2, 205-209 (1983)
DOI: 10.1177/096032718300200205


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