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Human & Experimental Toxicology
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Haemodynamic Studies in Eight Cases of Acute Colchicine Poisoning

Ph. Sauder

Service de Reanimation Medicale et Centre Anti-Poisons, C.H.U. B.P. No. 426, 67091 Strasbourg, France

J. Kopferschmitt

Service de Reanimation Medicale et Centre Anti-Poisons, C.H.U. B.P. No. 426, 67091 Strasbourg, France

A. Jaeger

Service de Reanimation Medicale et Centre Anti-Poisons, C.H.U. B.P. No. 426, 67091 Strasbourg, France

J.M. Mantz

Service de Reanimation Medicale et Centre Anti-Poisons, C.H.U. B.P. No. 426, 67091 Strasbourg, France

1 The authors performed haemodynamic studies in 8 cases of colchicine poisoning. The doses absorbed ranged between 9 and 160 mg (mean dose 39 mg). The haemodynamic study was performed between the 6th and 72nd h after intoxication, before and after plasma infusion (370 ml over a period of 20 minutes).

2 Four patients had severe shock with decreased cardiac index (CI) and increased systemic vascular resistance (SVR). Four patients had a hyperkinetic state with increased CI and decreased SVR. The four patients with cardiac failure died, the others recovered.

3 Haemodynamic study of acute colchicine poisoning is of therapeutic and prognostic interest. Hypovolaemia is always present. An initial decrease of cardiac performance is an index of severity with a lethal outcome.

Human & Experimental Toxicology, Vol. 2, No. 2, 169-173 (1983)
DOI: 10.1177/096032718300200201
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