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Effect of Calorie Restriction on the Fate of Hyperplastic Liver Nodules Induced by Concurrent Administration of Lasiocarpine and Thioacetamide

Department of Pathology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA

Marjorie V. Jago

CSIRO, Division of Animal Health, Animal Health Research Laboratory, Victoria, Australia

Janardan K. Reddy

Department of Pathology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA

1 Hyperplastic liver nodules were induced in F-344 rats by concurrent administration of lasiocarpine (50 ppm in diet) and thioacetamide (50 mg/kg body weight twice weekly) for 15 weeks.

2 The effect of carbohydrate calorie and total calorie restriction on the fate of hyperplastic liver nodules was examined.

3 The incidence of hepatocellular carcinoma was the same in all groups of rats irrespective of the magnitude of carbohydrate calorie restriction and 50% total calorie restriction.

4 These studies demonstrate that carbohydrate or total calorie restriction has no effect on the progression of hyperplastic nodules to hepatocellular carcinoma.

Human & Experimental Toxicology, Vol. 2, No. 1, 15-26 (1983)
DOI: 10.1177/096032718300200102


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