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Antithyroid Effect of Chlorpropamide?

Department of Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee DD 19SY

S. McLaren

Departments of Pharmacology and Therapeutics and Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee DD19SY

A.M.M. Shepherd

Division of Clinical Pharmacology, University of Texas Health Sciences Institute at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas

D. Maclean

Departments of Pharmacology and Therapeutics and Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee DD19SY

I.H. Stevenson

Departments of Pharmacology and Therapeutics and Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee DD19SY

C.G. Swift

Department of Geriatric Medicine, Kingston General Hospital, Beverly Road, Hull, North Humberside

T.E. Isles

Departments of Pharmacology and Therapeutics and Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee DD19SY

1 The relationship between plasma chlorpropamide concentration and thyroid function was examined in 87 maturity onset diabetic patients receiving chronic therapy.

2 Although plasma chlorpropamide concentration was weakly negatively correlated with serum thyroxine (r= 0.33, P< 0.01) the mean serum thyroxine and thyrotrophin (TSH) were not different from that of a matched control group of diabetics treated with diet alone.

3 Serum thyroxine was negatively correlated with the duration of diabetes in both groups.

4 These results suggest that chlorpropamide does not have a clinically significant antithyroid effect.

Human & Experimental Toxicology, Vol. 2, No. 1, 149-153 (1983)
DOI: 10.1177/096032718300200112


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