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Human & Experimental Toxicology
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Chronic Arsenic Poisoning in the North of Mexico

Mariano E. Cebrian

Secci6n de Toxicología, Centro de Investigación y de Estudios Avanzados del I.P.N., P.O. Box 14-740, México 14, D. F., México

Arnulfo Albores

Departamento de Bioquimica. Facultad de Medicina de la Universidad Autónoma de Coahuila, Torreón, Coah., México

Manuel Aguilar

Departamento de Bioquimica. Facultad de Medicina de la Universidad Autónoma de Coahuila, Torreón, Coah., México

Enrique Blakely

Secretaría de Agricultura y Recursos Hidráulicos, Jefatura de Protección y Ordenación Ecológica. Lerdo, Dgo., México

1 We compared the prevalence of signs and symptoms of chronic arsenic poisoning in two rural populations.

2 The arsenic concentration in the drinking water of the exposed population was 0.41 mg/l, and 0.007 mg/l in the control population.

3 The arsenic was present mainly (70%) in its pentavalent form.

4 The objective was to quantitate health effects and risks derived from chronic ingestion of arsenic in contaminated water.

5 In the exposed population, 21.6% of the sample, showed at least one of the cutaneous signs of chronic arsenic poisoning against 2.2% in the control town.

6 Non-specific symptoms were more prevalent in the exposed population and they occurred more frequently in those individuals with skin signs.

7 The relative risk of suffering a particular manifestation of poisoning, ranged from 1.9 to 36 times higher in the exposed population.

8 We estimated the risks above mentioned, which were derived from exposure to minute quantities of arsenic in a known proportion of its oxidation states during a life time period.

Human & Experimental Toxicology, Vol. 2, No. 1, 121-133 (1983)
DOI: 10.1177/096032718300200110
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