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Frequency and Markov chain analysis of amino acid sequences of mouse p53

Laboratory of Toxicokinetics and Pharmacokinetics, Faculty of Pharmacy, University of Mediterranean, Marseilles, France

The amino acid sequence of mouse p53 was measured according to two-and three-amino-acid sequences. The measured frequency and probability were compared with predicted frequency and probability. Of 389 two-amino-acidsequencesinmousep53,85 (21.851%) and27 (6.941%) sequences can be explained by the predicted frequency and probability accordingto a purely random mechanism. Of 188 non-appearing two-amino-acid sequences in mouse p53, 86 (45.745%) and 32 (17.021%) can be explained by the predicted frequency and probability according to a purely random mechanism; no more than two-amino-acid sequences inmousep53 canbe explained by a purelyrandom mechanism.

Key Words: amino acid sequence • mouse p53 • Markov chain • probability

Human & Experimental Toxicology, Vol. 19, No. 9, 535-539 (2000)
DOI: 10.1191/096032700670531579


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