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Human & Experimental Toxicology
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Assessment of thyroid function in pesticide formulators

S SA Zaidi

Department of Biochemistry, National Institute of Occupational Health, Meghani Nagar, Ahmedabad, Gujarat 380 016, India

V K Bhatnagar

S J Gandhi

M P Shah

P K Kulkarni

H N Saiyed

National Institute of Occupational Health (Indian Council of Medical Research), Meghani Nagar, Ahmedabad 380 016, India

Thirty male pesticide formulators exposed to the dust and liquid formulation of endosulfan, quinalphos, chlorpyriphos, monocrotophos, lindane, parathion, phorate, and fenvalerate and 20 comparable control subjects from the same area of study were examined for the evaluation of thyroid function tests. The level of TSH was elevated (about 28%) in pesticide formulators as compared to a control group, but the increase was statistically insignificant. Based on the individual TSH measurement, 3 of 30 formulators had isolated elevated levels of TSH and seem to have acquired sub-clinical hypothyroidism; five had TSH values slightly elevated to the upper boarder line (4.03,uIU/ml); and the majority of formulators (N= 22) had TSH values in the normal range varying from 1.29 to 3.9 pIU/ml. Total T3 was suppressed significantly (P <0.01) in formulators, while marginal decrease (about 7%) was noticed in T4 level. This studyindicatedthyroidfunctionimpairmentinfewpesticide formulators.

Key Words: thyroid hormone • endocrine disruptors • radioimmunoassay • hypothyroidism • hyperthyroidism • pesticides • formulators

Human & Experimental Toxicology, Vol. 19, No. 9, 497-501 (2000)
DOI: 10.1191/096032700677928536
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