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Acute delirium induced by intravenous trimethoprim–sulfamethoxazole therapy in a patient with the Acquired Immunodeficiency Syndrome

Division of Infectious Diseases, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA; University of Missouri-Kansas City School of Medicine, Green 4 Unit, 2411 Holmes Street, Kansas City, MO 64108, USA

The development of a rash in response to trimethoprim-sulfamethoxazole (TMP-SMX) administration is a fre-quent adverse reaction in people with the acquired immunodeficiency syndrome (AIDS). In contrast, there are no published reports in the English language literature describing TMP-SMX induced delirium in an AIDS patient. This report describes the development of frank delirium in a person with AIDS receiving TMP-SMX. The episode resolved completely within 72 h of withdrawal of the drug.

Key Words: Trimethoprim–sulfamethoxazole • drug–induced–delirium • psychosis • acquired immunodeficiency syndrom

Human & Experimental Toxicology, Vol. 19, No. 2, 149-151 (2000)
DOI: 10.1191/096032700678815666


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