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Human & Experimental Toxicology
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Amelioration of fluoride-induced hypocalcaemia by vitamins

D M Guna Sherlin

Jai Research Foundation, Valvada 396 108, India

R J Verma

Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad 380 009, India

Oral administration of sodium fluoride (40 mg/kg body weight) from day 6 of gestation to day 21 of lactation caused, compared with vehicle control, significantly lowered level of calcium and phosphorus in the serum of both P and F1 generation rats.Administration of vitamin C (50mg/kgbody weight), D (2 ng/0.2 ml olive oil/animal), E (2 mg/0.2 ml olive oil/animal) and a combination (vitamin C + D + E) along with NaF caused significant amelioration in serum calcium in P generation and serum phosphorus in both P and F1, generation rats as compared with only NaF-treated group. Serum calcium concentration was only partially recovered (P and F1 generation) on NaF withdrawal during lactation, as well as, on cotreatment (F1 generation) with vitamins. However, serum phosphorus level was significantly recovered on NaF withdrawal.

Key Words: fluoride • hypocalcaemia • vitamins • amelioratio

Human & Experimental Toxicology, Vol. 19, No. 11, 632-634 (2000)
DOI: 10.1191/096032700674624068
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