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Polycyclic aromatic hydrocarbons in placenta

Biostatistics Branch, Mail Drop A3-03, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709, USA

T D Zadorozhnaja

N Chislovska

Institute of Pediatrics, Obstetrics, and Gynecology, Kyiv, Ukraine

D O Hryhorczuk

School of Public Health, University of Illinois, Chicago, Illinois USA

M C Kennicutt, II

Geochemical and Environmental Research Group, Texas A&M University, College Station, Texas

R E Little

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina USA

Concentrations of chrysene, benz [a I anthracene, benzo [a I -pyrene, benzo [h lfluoranthene, indeno [1,2,3 -c,d] pyrene, dibenz [a,h I anthracene, and benzo [g,h,i] perylene were measured in placentas from 200 women from two cities in Ukraine, Kyiv and Dniprodzerzhinsk. The participants had no special exposures and were chosen from among subjects in an ongoing study of reproductive health. All seven of the polycyclic aromatic hydrocarbons (PAHs) were found in all placentas, with the sole exception of benzo [a I pyrene in one placenta. Chrysene was present at the highest concentrations, with median 1.38 ng/g dry weight. Dibenz[a,h]anthracene and benzo[g,h,ilperylene had the lowest concentrations; each had median 0.73 ng/g dry weight. Concentrations in Kyiv were slightly higher than those in Dniprodzerzhinsk, butthe differencewas significantonlyfor dibenz [a,h I anthracene. Dibenz [a,h] anthracene and benzo[g,h,ijperylene increased significantly with maternal body mass index, but other PAHs showed no such pattern. Placentas from deliveries in autumn or winter had slightly but not significantly higher concentrations. Concentrations were not related to maternal age. There were too few smokers in the sample for meaningful evaluation. No associations were seen between any of the placental PAH concentrations and birth weight of the infant.

Key Words: polycyclic aromatic hydrocarbons • placenta • birth weigh

Human & Experimental Toxicology, Vol. 19, No. 11, 597-603 (2000)
DOI: 10.1191/096032700671433928


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