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Human & Experimental Toxicology
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Radiation hormesis: its historical foundations as a biological hypothesis

E J Calabrese

L A Baldwin

Department of Environmental Health Sciences, School of Public Health, N 344 Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA

This paper represents the first systematic effort to describe the historical foundations of radiation hormesis. Spanning the years from 1898 to the early 1940‘s the paper constructs and assesses the early history of such research and evaluates how advances in related scientific fields affected the course of hormetic related research. The present effort was designed to not only address this gap in current knowledge, but to offer a toxicological basis for how the concept of hormetic dose-response relationships may affect the nature ofthe bioassay and its role in the risk assessment process.

Key Words: hormesis • low dose • stimulation • ß-curve • radiation

Human & Experimental Toxicology, Vol. 19, No. 1, 41-75 (2000)
DOI: 10.1191/096032700678815602
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