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Effects of occupational chronic co-exposure to n-hexane, toluen, and methyl ethyl ketone on NK cell activity and some immunoregulatory cytokine levels in shoe workers

Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandoan, Ankara

A Yücel

Department of Immunology, Faculty of Medicine, Gazi University, 06500, Beevler, Ankara

O Erdem

S Burgaz

Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330, Hipodrom, Ankara, Turkey

T mir

Department of Immunology, Faculty of Medicine, Gazi University, 06500, Beevler, Ankara

A E Karakaya

Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330, Hipodrom, Ankara, Turkey

A Karakaya

Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandoan, Ankara

1. 1 To evaluate the effects of occupational long-term coexposure to n-hexane, toluen, and methyl ethyl ketone (MEK) on NK cell activity and serum IL-2, g-IFN levels, we studied a group of workers employed in a shoe factory where the jobs include use of glues and adhesives containing mainly n-hexane, and at low concentrations, toluen and MEK.
   
2. 2 No differences were found in these parameters even in those workers with 3.3-fold higher mean levels of urine, 2,5-Hxdn and approximately twofold higher mean levels of urine hippuric acid as compared to controls.
   
3. 3 We conclude that chronic co-exposure to n-hexane, toluen, and MEK at these levels is not associated with an impairment on either NK cell activity or serum IL-2 and g-IFN levels.
   

Key Words: n-hexane • toluen • MEK • natural killer cell activity • cytokine

Human & Experimental Toxicology, Vol. 18, No. 9, 541-546 (1999)
DOI: 10.1191/096032799678845115


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