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Clinical impact of upper gastrointestinal tract injuries in glyphosate-surfactant oral intoxication

Y-C Peng

D-Z Hung

W-H Hui

D-Y Yang

Department of EmergencyMedicine, Taichung Veterans GeneralHospital, Taichung, Taiwan 40705, Republic of China

T-J Lin

Department of EmergencyMedicine, Taichung Veterans GeneralHospital, Taichung, Taiwan 40705, Republic of China; National Yang-Ming University, Taipei, Taiwan 112, Republic of China

1. 1 Fifty patients with glyphosate-surfactant oral ingestion were studied with upper gastrointestinal (UGI) endoscopic grading using Zargar's modified grading system for mucosal corrosive injury.
   
2. 2 Esophageal injury was seen in 68% of the patients, gastric injury in 72%, and duodenal injury in 16%. There were no grade 3 injuries. The upper gastrointestinal tract injuries caused by glyphosate-surfactant were minor in comparison with those by other strong acids.
   
3. 3 The WBC count, amount of glyphosate-surfactant ingested, length of hospital stay and the occurrence of serious complications increased markedly in the group which had grade 2 esophageal injuries. Thus, the severity of the esophageal injuries may be a prognostic factor for the patient with glyphosate-surfactant ingestion.
   
4. 4 The UGI endoscopy may be indicated for grading esophageal injury in patients who have ingested glyphosate-surfactant in amounts greater than 100 ml. Physicians should pay more attention to the patients with grade 2 or 3 esophageal injuries to prevent serious complications and to provide aggressive supportive care.
   

Key Words: glyphosate-surfactant • esophageal injury • endoscopy • corrosive injury

Human & Experimental Toxicology, Vol. 18, No. 8, 475-478 (1999)
DOI: 10.1191/096032799678847078


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