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Human & Experimental Toxicology
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*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CARBON
*CARBON BLACK
*NICKEL, ELEMENTAL
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Antibody forming cell response to nickel and nickel-coated fly ash in rats

S Dogra

A K Khanna

J L Kaw

Industrial Toxicology Research Centre, Post Box No. 80, Mahatma Gandhi Marg, Lucknow-226001, India

The potential of nickel as nickel chloride, native fly ash and Ni-coated fly ash to alter pulmonary and systemic immune response was evaluated upon intratracheal (I/T) exposure of rats. The animals were sensitised with sheep red blood cells (SRBC) through I/T and intraperitoneal (I/P) routes. Nickel exposure resulted in a decrease in the number of antibody forming cells (AFC) in lung associated lymph nodes (LALN) and spleen. In rats exposed to native fly ash there was a reduction in the number of AFC in LALN but not in spleen. The results did not demonstrate any significant difference in the immunosuppression of fly ash and Ni-coated fly ash exposed rats. The decrease in AFC formation in Ni-coated fly ash exposed animals was of a lesser magnitude than in rats exposed to Ni-alone.

Key Words: metals • nickel • fly ash • antibody • immunity

Human & Experimental Toxicology, Vol. 18, No. 5, 333-337 (1999)
DOI: 10.1191/096032799678840183
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