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Human & Experimental Toxicology
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Lead and calcium transport in human erythrocyte

J V Calderón-Salinas

M A Quintanar-Escorcia

Department of Biochemistry, CINVESTAV-IPN, P.O.Box 14-740, México City, México

M T González-Martínez

Department of Pharmacology, Faculty of Medicine, UNAM, México City, México

C E Hernández-Luna

Department of Biochemistry, Faculty of Biological Sciences, UANL, San Nicolás de los Garza, NL México

In this paper we report the lead (Pb) and calcium (Ca) uptake by erythrocyte ghosts. In both cases the transport was carried out by a passive transport system with two kinetic components (Michaelis-Menten and Hill). Pb and Ca were capable of inhibiting the transport of the other metal in a non-competitive way. Under hyperpolarization, the uptakes of Ca and Pb were enhanced and the Michaelis-Menten component prevailed. Both Ca and Pb uptakes were inhibited by N-ethyl-maleimide to the same extent. These results indicate that Pb and Ca share the same permeability pathway in human erythrocytes and that this transport system is electrogenic.

Key Words: lead • ion transport • calcium • human erythrocytes • ghosts

Human & Experimental Toxicology, Vol. 18, No. 5, 327-332 (1999)
DOI: 10.1191/096032799678840138
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This article has been cited by other articles:


Home page
 Hum Exp ToxicolHome page
M M. Vega, J C. Solorzano, and J V Calderon Salinas
The effects of dietary calcium during lactation on lead in bone mobilization: implications for toxicology
Human and Experimental Toxicology, August 1, 2002; 21(8): 409 - 414.
[Abstract] [PDF]


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