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To what extent are biomonitoring data available in chemical risk assessment?

A Hesbert

C Beausoleil

O Schneider

Institut National de Recherche et de Sécurité (INRS), Avenue de Bourgogne, B.P. N° 8 27, 54501 Vandoeuvre Cedex, France

1. 1 Chemical risk assessment integrates the identification of hazards and the human exposure levels which can be established from external and/or internal exposure data.
   
2. 2 The availability of biomonitoring and metabolism animal data, the skin penetration ability, and the existence of atmospheric threshold limit values were examined for twelve substances of the European first list of priority existing substances. This investigation was focused on workplace exposures and on urinary biomarkers of exposure. Appropriate biomonitoring data appeared to be available for two substances: styrene and trichloroethylene. Some biomonitoring research has been conducted on acrylonitrile, buta-1,3-diene, cyclohexane, 1,4-dichlorobenzene, hydrogen fluoride, 2-(2-methoxyethoxy)ethanol, however additional studies could be usefully carried out. No biomonitoring data are available for alkanes, C_10-13, chloro; benzene, C_10-13–alkyl derivatives; bis(pentabromophenyl)ether; diphenylether, octabromo-derivative.
   
3. 3 It was concluded that in some cases, biomonitoring data are either lacking or scarce. This is rather surprising since the selection of the substances of the priority list was based on high tonnage, widespread use, extent of human exposure, and toxicological concern. The development of biomonitoring information could be helpful in assessing individual or population chemical exposure whatever the source and route, and would result in both more realistic and more accurate risk assessments.
   

Key Words: risk assessment • biomonitoring • percutaneous penetration • chemical

Human & Experimental Toxicology, Vol. 18, No. 5, 322-326 (1999)
DOI: 10.1191/096032799678840147


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