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Exposure to environmental tobacco smoke during the first five years of life-results of a prospective birth cohort study

M Kulig

R. L. Bergmann

K. E. Bergmann,

C. P. Bauer

V. Wahn

F. Zepp

J. Forster

U. Wahn

Department of Pediatric Pneumology and Immunology Humboldt University of Berlin; D-13353 Berlin

Objective: To exanine links between environmental tobacco smoke (ETS)-exposure and urnary cotinine excretion during the first five years of life.

Design: Prospective birth cohiort study

Patients: 307 children from the Genran Multicenter Atopy Study (MAS-90)

Measurements and results: ETS-exposure was investigated by questionnaires about the parental smoking habits at home and by analysis of urinary cotinine exacetion by the children at 1 year, 4 years and 5 years of age (capillary gas-chromatography).

Results: From age 1 year to age 5 five years, the proportion of children growig up in smoker households remiained nearly constant (42%). However, 17% of the initial smoker households changed to non smoker households and vice versa. Within the smoker housholds the percentage of smoldng mothers increased from 19.9% to 25.7% and the percentage of smoking fathers decreased from 29.7% to 20.7%. 77% of the mothers and 60% of the fathers smoldng in the households when the child was 1 year old smoked continuously until children were 5 years old. The daily number of cigarettes smoked in the smoker households remained nearly constant (mean value: 6 cig/day).

Urnary cotinine excretion of the ETS-exposed children was found to peak at 1 year of age, decreasing significantly to 5 years of age (p = 0.02). From age 1 year to age 5 years there was a significant correlation between the urinary cotinine excretion of the children and the number of daily cigarettes smoked in the households (p < 0.01). At age 1 year, cotinine excretion was further influenced by the season of the year, the size of domestic apartment and the presence of an atopic mother. At age 5 years, cotinine excretion of the children living in smoker households and attending a kindergarten was significantly lower than that of children living in smoker households but not attending a kindergarten (< O.000 1).

Conclusion: Our results show that ETS-exposure passes through a peak during infancy. This suggests, that the reduced association between ETS-exposure and respiratory symptoms in children after age 2 years reported by earlier studies is due to an agedependent reduction of the ETS-exposure.

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