This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Calderón-Salinas, J V Articles by González-Martínez, M T Search for Related Content PubMed PubMed Citation Articles by Calderón-Salinas, J V Articles by González-Martínez, M T Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL LEAD, ELEMENTAL POTASSIUM TRIFLUOPERAZINE Social Bookmarking                   What's this?

Effect of lead on the calcium transport in human erythrocyte

Department of Biochemistry, CINVESTAV-IPN, México City, México

M A Quintanar-Escorza

Department of Biochemistry, CINVESTAV-IPN, México City, México

C E Hernández-Luna

Department of Biochemistry, Faculty of Biological Sciences, UANL, San Nicolás de los Garza, NL, México

M T González-Martínez

Department of Pharmacology, Faculty of Medicine, UNAM, México City, México

In this paper we study the calcium uptake in the erythrocyte, a non-excitable cell. This uptake is performed through a passive transport system with two kinetic components (Michaelis-Menten and Hill). The uptake of calcium seems to be driven by voltage through its electrophoretical effect. Lead is capable of inhibiting calcium uptake in a non-competitive manner. As it has been described in other systems, lead is also capable of inhibiting calcium efflux by inhibiting Ca(Mg)-ATPase. Under physiological conditions, the function of ATPase reduces the effect of lead on calcium influx. However, in chronic intoxication a small increment of intracellular calcium is observed, indicating that lead is affecting calcium efflux mainly. We discuss the effects of lead on calcium equilibrium in erythrocytes.

Key Words: lead • transport • calcium • human erythrocytes • lead intoxication

Human & Experimental Toxicology, Vol. 18, No. 3, 146-153 (1999)
DOI: 10.1177/096032719901800303


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				R Sivaprasad, M Nagaraj, and P Varalakshmi Combined efficacies of lipoic acid and meso-2,3-dimercaptosuccinic acid on lead-induced erythrocyte membrane lipid peroxidation and antioxidant status in rats Human and Experimental Toxicology, April 1, 2003; 22(4): 183 - 192. [Abstract] [PDF]

				M M. Vega, J C. Solorzano, and J V Calderon Salinas The effects of dietary calcium during lactation on lead in bone mobilization: implications for toxicology Human and Experimental Toxicology, August 1, 2002; 21(8): 409 - 414. [Abstract] [PDF]