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Human & Experimental Toxicology, Vol. 18, No. 2, 82-87 (1999)
DOI: 10.1177/096032719901800204
© 1999 SAGE Publications

A sheep model for continuous intrathecal infusion of test substances

Samuel J Hassenbusch

The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd (Box 064), Houston, Texas 77030, USA

William C Satterfield

The University of Texas, MD Anderson Cancer Center-Science Park, Rt. 2, Box 151-B1, Bastrop, Texas 78602, USA

Tamara Lee Gradert

The University of Texas, MD Anderson Cancer Center-Science Park, Rt. 2, Box 151-B1, Bastrop, Texas 78602, USA

Pharmaceutical research and new drug development rely extensively on animal research. The development of novel agents for intrathecal administration requires preclinical studies of toxic effects in an animal model. We have developed a nonrodent animal model for this purpose. Our sheep model:

1 Is an animal whose neural axis is similar to the human

2 Allows for the percutaneous placement of intrathecal catheters

3 Has minimal possibilities of infection because the infusion system is totally implanted

4 Provides continuous infusion of the test agent

5 Generates behavioral, motor, neurological and histo-pathological information so that safety guidelines can be established prior to preclinical studies.

Key Words: toxicity testing • intrathecal • implanted pump • sheep


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