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Detection of germ cell genotoxic potential, of carbon disuiphide using sperm head shape abnormality test

K G Patel

A K Gautam

K Agarwal

B A Shah

H N Saiyed

Division of Reproductive Toxicology, National Institute of Occupational Health, Meghani Nagar, Ahmedabad 380016, India

1. 1 Adult male albino rats (CF Strain) were administered i.p. CS₂ dissolved in cotton seed oil at doses of 25, 50, 100 and 200 mg/kg b.wt. for a period of 60 days. Effect of CS, on epididymis, adrenal weight, sperm count and sperm head shape abnormality was studied.
   
2. 2 Epididymal weight remained unaltered in 25, 50 and 100 mg/kg CS₂ treated groups, whereas in highest dose of CS₂ treated (200 mg/kg) group a non-significant reduction in epididymis weight was observed. A slight increase in adrenal weight was observed in lower doses groups (25 and 50 mg/kg) while a considerable decrease in adrenal weight was noted in highest dose (200 mg/kg) of CS, treated group in the present study.
   
3. 3 An increase in sperm head shape abnormality and decrease in sperm count was observed in all the CS₂ treated groups. However, the changes were statistically significant only after higher dose of CS₂ treatment as compared to control.
   
4. 4 This study suggests that CS₂ may have the potential to induce adverse effects on male reproductive system of rats. Sperm head shape abnormality assay used in this study also elicits germ cell genotoxic potential of carbon disulphide.
   

Key Words: carbon disulphide • sperm abnormality • male reproduction • epididymis • adrenal

Human & Experimental Toxicology, Vol. 18, No. 12, 731-734 (1999)
DOI: 10.1191/096032799678839608


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