This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Saito, T Articles by Takeichi, S Search for Related Content PubMed PubMed Citation Articles by Saito, T Articles by Takeichi, S Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB PANCURONIUM BROMIDE PENTOBARBITAL Social Bookmarking                         What's this?

Effects of muscle relaxants on EEG, ABR and EMG in rabbits

Department of Forensic Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan

I Yamamoto

Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan

X-L Huang

N Yukawa

M Osawa

S Takeichi

Department of Forensic Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan

The effects of baclofen and pancuronium bromide on evoked electromyogram (EMG), cortical electroencephalogram (EEG) and auditory brainstem responses (ABR) were studied in pentobarbital anesthetized normal rabbits. Evoked EMG was measured in the gastrocnemius muscle by electrical stimulation of the sciatic nerve. Intravenous injection of baclofen decreased EEG and arterial blood pressure and light reflex, however, it had no significant influence on EMG or ABR at doses of 10 and 20 mg/kg/h. Pancuronium bromide immediately inhibited respiration, decreased EEG and EMG, however, it had no significant influence on arterial blood pressure, ABR, or light reflex, at doses of 0.4 and 1.0 mg/kg/h in anesthetized rabbits. ABR waves were observed until just before cardiac arrest with both of the muscle relaxants. It is suggested that ABR are not influenced by central or peripheral muscle relaxants, or by pentobarbital.

Key Words: baclofen • pancuronium bromide • evoked electromyogram • electroencephalogram • auditory brainstem responses

Human & Experimental Toxicology, Vol. 18, No. 12, 718-723 (1999)
DOI: 10.1191/096032799678839635


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. R. Rajasekaran, Y. Jiang, V. Bhargava, R. Littlefield, A. Lee, R. L. Lieber, and R. K. Mittal Length-tension relationship of the external anal sphincter muscle: implications for the anal canal function Am J Physiol Gastrointest Liver Physiol, August 1, 2008; 295(2): G367 - G373. [Abstract] [Full Text] [PDF]