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Human & Experimental Toxicology
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Effect of single neonatal vitamin D3 treatment (hormonal imprinting) on the bone mineralization of adult non-treated and dexamethasone treated rats

Cs Karabélyos

Department of Genetics, Cell-and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary

Cs Horváth

1st Department of Medicine, Semmelweis University of Medicine, Budapest, Hungary

I Holló

1st Department of Medicine, Semmelweis University of Medicine, Budapest, Hungary

G Csaba

Department of Genetics, Cell-and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary

Hormonal imprinting (the first encounter between the hormone and receptor after birth) is needed for the normal development of receptor. Presence of the appropriate hormone in excess, or its absence, as well as presence of hormone-like molecules able to bind to the maturing receptor in this time, can cause faulty imprinting. In this experiment the effect of neonatal treatment with a single dose of 0.05 mg cholecalciferol (vitamin D3) was studied by bone densitometry. The treatment caused significant decrease of body weight in 3-month old females and also significant reduction of bone mineral density (BMD) and bone mineral content (BMC) in males. Dexamethasone treatment of 3-month old rats for 10 days increased BMD in males and BMC in females without affecting body weight. The double treatment (vitamin D neonatally and dexamethasone when adult) decreased the body weight of both sexes and increased BMD in males, and BMC, BMD/bw and BMC/bw in both sexes, related to the control or the only vitamin D treated groups. Considering the hormonal imprinting effect of neonatal vitamin D treatment at glucocorticoid receptorial level in other experiments, similar effects also can be supposed for vitamin D itself, manifested in the changes of bone mineralization.

Key Words: vitamin D • bone • glucocorticoid • hormonal imprinting • cholecalciferol • hormone

Human & Experimental Toxicology, Vol. 17, No. 8, 424-429 (1998)
DOI: 10.1177/096032719801700803
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[Abstract] [Full Text] [PDF]


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