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Unique cerebral dysfunction following triphenyltin acetate poisoning

Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, and National Yang Ming University, Taiwan 40705, Republic of China

Dong-Zong Hung

Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, and National Yang Ming University, Taiwan 40705, Republic of China

Chia-Hung Kao

Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, and National Yang Ming University, Taiwan 40705, Republic of China

Wei-Hsiung Hu

Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, and National Yang Ming University, Taiwan 40705, Republic of China

Dar-Yu Yang

Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, and National Yang Ming University, Taiwan 40705, Republic of China

1 In animal studies, TPTA was found to be neurotoxic. In humans, variable CNS pictures have been described with or without significant EEG findings. Brain CT does not usually reveal any abnormalities.

2 Our patient presented with intermittent unique spontaneous involuntary movement of hands, facial twitching, silly smile and crying. Diplopia, drowsiness, giddiness, vertigo, bidirectional nystagmus, impairment of calculation ability, as well as disorientation to time, people and place also developed. EEG showed mild cortical dysfunction without seizures. MRI and Tc-99m HMPAO brain SPECT revealed no significant findings. TPTA may cause cellular dysfunction of brain without structural damage, which results in variable CNS clinical presentations.

3 Nadir of leucopenia was noted on the sixth day after consumption of TPTA. Liver impairment occurred on the ninth day. Borderline demyelinated neuropathy developed on the fifty-third day. CNS abnormalities, delayed peripheral neuropathy, hepatitis and leucopenia deserve monitoring for a prolonged period, even when the victim initially presents with GI upset only after consumption of TPTA.

Key Words: triphenyltin acetate • cerebral dysfunction • delayed peripheral neuropathy • leucopenia

Human & Experimental Toxicology, Vol. 17, No. 7, 403-405 (1998)
DOI: 10.1177/096032719801700707


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