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Human & Experimental Toxicology
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*ATROPINE
*SOMAN
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*Poisoning
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A comparison of the efficacy of new asymmetric bispyridinium oxime BI-6 with other oximes (obidoxime, HI-6) against soman in rats

J Kassa

Purkyne Military Medical Academy, Hradec Králové, Czech Republic

1 The influence of three oximes (obidoxime, HI-6 and the new asymmetric bispyridinium oxime BI-6) in combination with atropine on soman-induced cholinergic and stressogenic effects in rats was studied.

2 The oxime BI-6 produced significantly higher reactivation of soman-inhibited blood and diaphragm cholinesterases than obidoxime. On the other hand, its reactivating effect was not so high as the effect of the oxime HI-6.

3 There were not significant differences in the reactivation of soman-inhibited brain acetycholinesterase among all three oximes tested.

4 The influence of the oxime BI-6 on soman-induced stressogenic effects was greater than the antistressogenic effects of HI-6 or obidoxime at 1 h or 3 h following soman poisoning.

5 These findings confirm that the oxime BI-6 has no definite advantages over HI-6 in the antidotal treatment of soman poisoning but BI-6 is significantly more effective in rats than obidoxime, one of the oximes presently in use.

Key Words: soman • BI-6 • HI-6 • obidoxime • atropine • acetylcholinesterase

Human & Experimental Toxicology, Vol. 17, No. 6, 331-335 (1998)
DOI: 10.1177/096032719801700608
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