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Oral aluminum administration to rats with normal renal function. 2. Body distribution

Departamento de Química Biológica y de, Analiítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires

Gladys Gálvez

Departamento de Química Biológica y de, Analiítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires

Gladys Pérez

Departamento de Química Biológica y de, Analiítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires

Jorge Stripeikis

Departamento de Química Inorgánica, Analiítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires

Mabel Tudino

Departamento de Química Biológica y de, Analiítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires

Alcira Nesse

Departamento de Química Biológica y de, Analiítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires

Aluminum (Al) has no known physiological function and is not considered an essential dietary compound. Nowadays, it is recognized as an element that can produce adverse effects on biological systems. The present study determined Al partitioning in the body compartments of rats that have been orally exposed for 15 weeks. Three experimental groups were studied: Controls (C, n=19), T_Al-1 (n=10) rats receiving daily doses of Al citrate (1.0 mmol/g body weight) by gavage and T_A1-2 (n=13), receiving Al citrate with the drinking water (100 mmol/ l). At the end of the experimental period, the Al contents of organs and sera were determined. Results are expressed as median and range values. Comparing the T_Al-2 rats with the control ones, remarkable Al accumulation could be observed in serum (4.8/2.7 - 16.3 vs 0.4/0.2 - 1.2 mmol/l, P50.001), bone (3.33/1.78 - 4.85 vs 1.00/0.48 - 1.59 mmol/ g, P50.001), kidney (2.33/0.96 - 3.15 vs 0.52/0.22 - 2.07 mmol/g, P50.001), spleen (2.22/0.70 - 4.19 vs 0.27/ 0.11 - 0.36 mmol/g, P50.001) and liver (0.60/0.42 - 0.91 vs 0.24/0.14 - 0.78 mmol/g, P50.01) while brain Al content was not significantly increased. Aluminum levels were raised in the T_Al-1 group only in serum (2.8/1.3 - 10.4 mmol/ g, P50.001), bone (1.85/1.00 - 3.41 mmol/g, P50.001) and kidney (1.74/0.96 - 2.07 mmol/g, P50.01). Bone Al concentration increased in a dose-dependent manner (T_Al-2 vs T_Al-1, P50.001). The results demonstrate different tissue Al accumulation in rats chronically exposed to Al citrate, irrespective of their intact renal function.

Key Words: oral aluminum • bone aluminum accumulation • serum aluminum • aluminum toxicity • body aluminum distribution

Human & Experimental Toxicology, Vol. 17, No. 6, 318-322 (1998)
DOI: 10.1177/096032719801700606


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