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Urinary cadmium as indicator of renal cadmium in humans: an autopsy study

Department of Toxicological Chemistry, Medical University of Lodz, 90-151 Lód, Muszyskiego 1, Poland

Jerzy K Piotrowski

Department of Toxicological Chemistry, Medical University of Lodz, 90-151 Lód, Muszyskiego 1, Poland

Joanna K Subdys

Department of Toxicological Chemistry, Medical University of Lodz, 90-151 Lód, Muszyskiego 1, Poland

Adam Gross

Department of Forensic Medicine, Collegium Medicum, Jagiellonian University, 31-531 Kraków, Grzegórzecka 16, Poland

Objective: To estimate the equivalent cadmium levels in renal cortex and in urine, as based on autopsy analysis of subjects not exposed to cadmium occupationally.

Methods: The levels of Cd were determined in renal cortex, liver, urine and urinary bladder of 39 subjects deceased at the age 42+14 years. Flame atomic absorption spectrometry (kidneys, liver) and flameless AAS (urine, bladder) were used.

Results: The urinary cadmium level determined post mortem is strongly correlated with the renal Cd levels. Eliminating cases with high urinary proteins and extrapolating from sets of data with elevated urinary protein concentration to its normal range yielded a value of 1.7 mg/g creatinine as equivalent to the renal level of 50 mg/g w.w.

Conclusions: It seems possible to use monitoring data for cadmium in urine and in renal cortex in a coherent way.

Key Words: cadmium • urine • kidney cortex • liver • humans

Human & Experimental Toxicology, Vol. 17, No. 6, 302-306 (1998)
DOI: 10.1177/096032719801700603


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