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Uptake by man of aluminium in a public water supply

Biomedical Research, AEA Technology, 551 Harwell, Didcot, Oxon OX11 0RA, UK

R J Talbot

Biomedical Research, AEA Technology, 551 Harwell, Didcot, Oxon OX11 0RA, UK

D Newton

Biomedical Research, AEA Technology, 551 Harwell, Didcot, Oxon OX11 0RA, UK

J P Day

Department of Chemistry, University of Manchester, Manchester M11 9PL, UK

S J King

Department of Chemistry, University of Manchester, Manchester M11 9PL, UK

L K Fifield

Department of Nuclear Physics, Australian National University, Canberra ACT, Australia

1 After overnight fasting, two young male adults each received a single oral dose of 100 Bq ²⁶Al in tap water. Coincidence gamma-ray spectrometry and accelerator mass spectrometry were used to determine the ²⁶Al content of excretion collections and of blood samples.

2 Close to 100% of the intake was recovered in faeces during the first 7 days. Gastro-intestinal uptake, determined by comparing urinary excretion with patterns previously established following intravenous administration of ²⁶Al, averaged 0.22% in the two subjects.

3 Uptake fractions based on comparisons of blood concentration following ingestion and injection were much lower, but were judged to be unreliable. It is concluded that aluminium present in most water supplies is unlikely to contribute as much as 1% of a typical daily uptake of 10 mg from food.

Key Words: aluminium • bio]availability • man • water Correspondence: ND Priest

Human & Experimental Toxicology, Vol. 17, No. 6, 296-301 (1998)
DOI: 10.1177/096032719801700602


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