This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Johnson, T. E Articles by Bruunsgaard, H. Search for Related Content PubMed PubMed Citation Articles by Johnson, T. E Articles by Bruunsgaard, H. Pubmed/NCBI databases Medline Plus Health Information Seniors' Health Social Bookmarking                         What's this?

Implications of hormesis for biomedical aging research

Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, 80309, USA

Helle Bruunsgaard

Department of Infectious Diseases, Rigshosptitalet, University of Copenhagen, 220 Copenhagen N, Denmark

Rather than being an exception, non-linearity between dose and response are the rule in biological systems. It might even be anticipated that at some doses a response opposite to that seen at high doses could be elicited (hormesis). Such non-linearity with dose has multiple implications for numerous aspects of biomedical research on aging and for experimental design. Moreover, the implications of such non-linearity are such that governmental regulatory activities and other areas of public health administration will be affected to a large extent once hormesis is widely recognized. The implications with regard to environmental intervention and subsequent regulatory decisions will certainly profoundly affect the political process, as well.

Key Words: stress resistance • aging • life span • longevity • induced resistance • psychosocial hormesis • cardiac hormesis • alcohol hormesis

Human & Experimental Toxicology, Vol. 17, No. 5, 263-265 (1998)
DOI: 10.1177/096032719801700509


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. I. Yashin, J. W. Cypser, T. E. Johnson, A. I. Michalski, S. I. Boyko, and V. N. Novoseltsev Heat Shock Changes the Heterogeneity Distribution in Populations of Caenorhabditis elegans: Does It Tell Us Anything About the Biological Mechanism of Stress Response? J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2002; 57(3): B83 - 92. [Abstract] [Full Text] [PDF]