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Human & Experimental Toxicology
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What's this?

Incorporating hormesis in the routine testing of hazards

A John Bailer

Center for Environmental Toxicology and Statistics, Department of Mathematics and Statistics, Oxford, Ohio 45056, USA

James T Oris

Department of Zoology Miami University, Oxford, Ohio 45056, USA

The phenomenon of subtoxic stimulation of organism response is not uncommon in aquatic toxicology experiments. We describe the presence of hormesis in both growth and reproduction experiments in aquatic toxicology where these responses are observed in both animals and plants and at different trophic levels of an ecosystem. The implications of ignoring hormetic responses in the analysis of toxicity data are discussed. In particular, we note that specification of models that explicitly cannot accommodate or remove potential effects of hormesis may lead to biased potency estimates. Further, the presence of hormesis has implications for the design of toxicology experiments, with the spacing of concentration test conditions being critical.

Key Words: Effective Concentration (EC) • regression • monotonic pattern

Human & Experimental Toxicology, Vol. 17, No. 5, 247-250 (1998)
DOI: 10.1177/096032719801700505
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