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Human & Experimental Toxicology
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Abnormal antioxidant system in erythrocytes of mercury-exposed workers

Mary Luci de Souza Queiroz

Departamento de Farmacologia, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Socrates Calvoso Pena

Departamento de Farmacologia, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Tereza Sueko Ide Salles

Hemocentro, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Eduardo Melo de Capitani

Departamento de Medicina Preventiva, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Sara Teresinha Olalla Saad

Hemocentro, Universidade Estadual de Campinas, Campinas, SP, Brazil, Departamento de Clinica Médica. Universidade Estadual de Campinas, Campinas, SP, Brazil.

To investigate the effects of chronic exposure to mercury we studied the red cell antioxidant system in mercury-exposed workers through the evaluation of reduced glutathione, catalase and superoxide dismutase systems. Oftheseworkers, somewerebeingexposedatthetimeand had presented urinary mercury levels considered safe for occupational exposure for at least 3 months prior to the initiation of this study, and others had been on leave for at least 6 months because of intoxication symptoms. Reduced glutathione levels were lower and catalase activity was higher in the workers which were still being exposed, compared to those on leave and controls. No differences were observed between the workers on leave and controls.

Key Words: mercury • occupational exposure • catalase • glutathione • superoxide dismutase • erythrocyte

Human & Experimental Toxicology, Vol. 17, No. 4, 225-230 (1998)
DOI: 10.1177/096032719801700405
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