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Human & Experimental Toxicology
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Acute paraquat poisoning: increased toxicity in one case with high alcohol intake

D Ernouf

Laboratoire de Toxicologie, Faculté de Pharmacie, 31 Avenue Monge, 37200 Tours, France, Laboratoire de Pharmacologie et Toxicologie Cliniques, CHU Bretonneau, 37044 Tours Cedex, France

N Boussa

Laboratoire de Pharmacologie et Toxicologie Cliniques, CHU Bretonneau, 37044 Tours Cedex, France

A Legras

Service de Réanimation Médicale, CHU Bretonneau, 37044 Tours Cedex, France

H Dutertre-Catella

Laboratoire de Toxicologie, Faculté de Pharmacie, 31 Avenue Monge, 37200 Tours, France

Human paraquat poisoning from accidental or intentional ingestion is very often fatal. According to the amount of paraquat involved, death can occur within hours or weeks following ingestion. The inefficacy of the various treatments undertaken have led to determine prognostic factors based upon the evolution of plasma and urine paraquat concentrations or of usual biochemical parameters. We report one case of acute poisoning which, although the ingested dose of paraquat was not massive (550 mg/kg7 1) and the severity indices were in favour of a delayed fatal outcome, has ended in an early death. The high blood alcohol level of the patient (3.34 g l7 1) seems to be the main cause of the precocity of this death (86th hour).

Key Words: paraquat • alcohol • pronostic index • toxicokinetics • human study

Human & Experimental Toxicology, Vol. 17, No. 3, 182-184 (1998)
DOI: 10.1177/096032719801700310
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