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Transgenerational effect of a single neonatal benzpyrene treatment on the glucocorticoid receptor of the rat thymusDepartment of Genetics, Cell and Immunobiology, Semmelweis University of Medicine, H-1445 Budapest, POB 370, Hungary
Department of Genetics, Cell and Immunobiology, Semmelweis University of Medicine, H-1445 Budapest, POB 370, Hungary Hormonal imprinting is provoked perinatally by the appropriate hormone on its receptor, causing a life-long adjustment of the connection between the two participants. Faulty imprinting is caused by the presence of molecules similar to the hormone in this critical period, which results in a persistent alteration of the receptor. In the present experiment the transgenerational imprinting effect of a steroid-like environmental pollutant, benzpyrene, on the receptor binding capacity of filial thymic dexamethasone and uterine estrogen receptors was studied. The receptor density (Bmax) of the thymic glucocorticoid receptors of the males was reduced up to the third (F2) generation. In females this reduction was observed only in the F1 generation of treated animals. There was no change in receptor affinity (Kd). Uterine estrogen receptors were not subjected to transgenerational imprinting. The experiments demonstrate (1) the possibility of the transgenerational transmission of imprinting effect, (2) the differences of steroid receptors in different organs, and (3) the differences of male's and female's reactions from this aspect. The results call attention to the dangers of perinatal aromatic hydrocarbon exposition to the progeny generations.
Key Words: hormonal imprinting • transgenerational effects • aromatic hydrocarbon • steroid receptors • glucocorticoid receptors • estrogen receptors
Human & Experimental Toxicology, Vol. 17, No. 2,
88-92 (1998) This article has been cited by other articles:
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