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Human & Experimental Toxicology
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Organotin compounds in trimethyltin-treated rats and in human brain in Alzheimer's Disease

F. Martin

Laboratoire de Photophysique et Photochimie Moleculaire, Universite de Bordeax, France

FM Corrigan

Argyll and Bute Hospital, Lochgilphead,.Argyll, PA31 8LD

Ofx Donard

Laboratoire de Photophysique et Photochimie Moleculaire, Universite de Bordeax, France

J. Kelly

Department of Pharmacology, University College Galway, Ireland

Jao Besson

Department of Psychiatry, St Thomas Hospital, London

DF Horrobin

Scotia Pharmaceuticals Limited, Woodbridge Meadows, Guildford, Surrey, UK

As blood tin concentrations are elevated in Alzheimer's disease and as some low molecular weight organotin compounds are neurotoxic, we have attempted to detect organotins in brain in Alzheimer's Disease. First we measured the concentration of trimethyltin (TMT) in the brains of rats which had been exposed to memory- impairing concentrations of TMT and, as the method of linking hydride generation, cryogenic trapping, gas chromatographic separation and atomic absorption spec trophotometric detection permitted the measurements of organotin compounds when the total tin was greater than 0.2 nanograms, we applied these techniques to human brain tissue, some of which showed neuropathological evidence of Alzheimer's Disease. No low molecular weight organotin compounds were detected in the human brain tissue, but it is possible that tin may be complexed with large organic molecules, the hydrides of which would not be volatile, but which could be identified by liquid chromatography.

Key Words: organotin • brain • Alzheimer's Disease

Human & Experimental Toxicology, Vol. 16, No. 9, 512-515 (1997)
DOI: 10.1177/096032719701600906
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