SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Human & Experimental Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Anane, R.
Right arrow Articles by Creppy, E. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anane, R.
Right arrow Articles by Creppy, E. E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Transplacental passage of aluminium from pregnant mice to fetus organs after maternal transcutaneous exposure

Rachid Anane

Laboratory of Toxicology and Applied Hygiene, Faculty of Pharmaceutical Sciences, University Bordeaux 2, Victor Segalen, 146, Rue Léo-Saignat-F33076 Bordeaux, France

Michèlle Bonini

Laboratory of Toxicology and Applied Hygiene, Faculty of Pharmaceutical Sciences, University Bordeaux 2, Victor Segalen, 146, Rue Léo-Saignat-F33076 Bordeaux, France

Edmond Ekué Creppy

Laboratory of Toxicology and Applied Hygiene, Faculty of Pharmaceutical Sciences, University Bordeaux 2, Victor Segalen, 146, Rue Léo-Saignat-F33076 Bordeaux, France

Aluminium is present in tap water, antiperspirants and cosmetics up to 20%. Teratogenicity of aluminium was clearly identified after per os or intravenous administra tion. Malformations and other alterations by aluminium intoxication were evaluated in fetus. In the present study, we investigated the possible transplacental passage of aluminium and its accumulation in the tissue after cutaneous uptake. Female Swiss mice received alumi nium chloride by cutaneous way (0.4 µg/day) during 20 days of gestation. The samples were assayed for alumi nium quantification by graphite furnace atomic absorp tion with Zeeman correction. This treatment led to an increase of aluminium in maternal and fetus samples (serum, amniotic fluid and organs) as compared to controls.

Key Words: aluminium • cutaneous application • transplacental passage • fetus • electrothermal atomic absorption spectrometry

Human & Experimental Toxicology, Vol. 16, No. 9, 501-504 (1997)
DOI: 10.1177/096032719701600904
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement