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Changes in the arterial blood pressure, heart rate and normal ECG parameters of rat after envenomation with Egyptian cobra (Naja haje) venom

Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt

Ismail M Abdel-Nabi

Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt

1 The effect of Egyptian cobra (Naja haje) venom on the normal electrical activity of the cardiac muscles (ECG) and arterial blood pressure of envenomated rats were investigated in this study.

2 Rats were divided into three groups. The first group was injected im with saline and considered as control group. Rats of the second and third groups were injected IM with 0.02 µg and 0.04 µg cobra venom/ gim b.wt, respectively.

3 Mean blood pressure (MBP), heart rate (HR) and four different ECG parameters (PR and QT intervals, R and T wave amplitudes) were measured over 1 h following envenomation.

4 The low dose (0.02 µg/g) of N. haje venom caused hypotension accompanied by an increase in the HR, whereas hypertension and bradycardia developed after injection of the high dose (0.04 µg/g) of venom.

5 There was a decrease in the P-R interval after administration of the low dose and prolongation of it after the high dose. The Q-T interval and R-wave amplitude were significantly increased after injection of both doses. T-wave amplitude was significantly elevated only after injection of the high dose.

6 The present results indicate that the Egyptian cobra (N. haje) venom significantly alters the arterial blood pressure and ECG parameters of envenomated rats. This suggests that impairment of the electrical activity of cardiac muscle may be one of the reasons why victims of cobra bite die.

Key Words: N. haje • cobra venom • haemodynamic effects • ECG changes • rat • cardiac dysfunction

Human & Experimental Toxicology, Vol. 16, No. 6, 327-333 (1997)
DOI: 10.1177/096032719701600606


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