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Human & Experimental Toxicology
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Defective neutrophil function in workers occupationally exposed to hexachlorobenzene

Mls Queiroz

Department of Pharmacology/Hemocentre, State University of Campinas

C. Bincoletto

Department of Pharmacology/Hemocentre, State University of Campinas

Rcr Perlingeiro

Department of Pharmacology/Hemocentre, State University of Campinas

CA Souza

Department of Clinical Medicine, F.C.M., State University of Campinas, Campinas

H. Toledo

Adolfo Lutz Institute, São Paulo, Brazil

In this work we have studied the respiratory burst and chemotaxis of polymorphonuclear leukocytes from 51 workers exposed to chlorinated compounds, which were compared with those of non-exposed, age- and sex- matched invididuals. These two neutrophil functions were significantly reduced as compared to controls. No correlation was observed between the length of exposure, hexachlorobenzene (HCB) blood concentrations and neu trophil chemotaxis or the extent of nitroblue tetrazolium reduction.

Key Words: hexachlorobenzene • chemotaxis • respiratory burst • humans

Human & Experimental Toxicology, Vol. 16, No. 6, 322-326 (1997)
DOI: 10.1177/096032719701600605
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